Synthesis and studies on the biophysical activity of human lung surfactant peptide SP-C and its N-terminal fragments.

Abstract

Human lung surfactant peptide SP-C and two of its N-terminal fragments were prepared by SPPS and their biophysical activities investigated in vitro using a pulsating bubble surfactometer. These studies demonstrated that even low doses of the synthetic peptides with the natural human sequence of SP-C in combination with reconstituted lipid mixtures causes a drastic decrease of surface tension.