{"title":"Use of nitrous oxide to dissociate the non-specific and specific components of the human auditory N1","authors":"Elizabeth W Pang , Barry Fowler","doi":"10.1016/S0168-5597(97)00049-X","DOIUrl":null,"url":null,"abstract":"<div><p>The components of the N<sub>1</sub><span><span> are thought to be related to sensory functioning (Components 1 and 2) and arousal (Component 3). To provide direct evidence for the involvement of Component 3 in arousal, we hypothesized that it should be more sensitive to the anesthetic gas </span>nitrous oxide (N</span><sub>2</sub>O) than Component 1. Using the technique of selective adaptation, 30 blocks of 5 tones were presented at 1 min intervals to 9 subjects who breathed air, 25% and 35% N<sub>2</sub>O. As hypothesized, the amplitude of Component 3 was significantly reduced in a dose-dependent manner by N<sub>2</sub>O, but the amplitude of Component 1 was not, although the latter showed some evidence of a decrease at 25% N<sub>2</sub>O.</p></div>","PeriodicalId":100401,"journal":{"name":"Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section","volume":"104 6","pages":"Pages 555-558"},"PeriodicalIF":0.0000,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0168-5597(97)00049-X","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016855979700049X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The components of the N1 are thought to be related to sensory functioning (Components 1 and 2) and arousal (Component 3). To provide direct evidence for the involvement of Component 3 in arousal, we hypothesized that it should be more sensitive to the anesthetic gas nitrous oxide (N2O) than Component 1. Using the technique of selective adaptation, 30 blocks of 5 tones were presented at 1 min intervals to 9 subjects who breathed air, 25% and 35% N2O. As hypothesized, the amplitude of Component 3 was significantly reduced in a dose-dependent manner by N2O, but the amplitude of Component 1 was not, although the latter showed some evidence of a decrease at 25% N2O.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
