P Schmezer, C Eckert, U M Liegibel, R G Klein, H Bartsch
{"title":"Use of transgenic mutational test systems in risk assessment of carcinogens.","authors":"P Schmezer, C Eckert, U M Liegibel, R G Klein, H Bartsch","doi":"10.1007/978-3-642-46856-8_29","DOIUrl":null,"url":null,"abstract":"<p><p>Two transgenic in vivo mutation assays are described which are based on LacZ (Muta Mouse) and LacI (Big Blue) shuttle vector systems. Their utility has already been explored by a number of investigators including our laboratory. The evaluation of data derived from these assays confirm that they offer a practical method for studying mutagenic activity and mechanism in a wide range of tissues including those of the respiratory and gastrointestinal tract. Therefore, these transgenic mutation assays are valuable tools to assess the organotropic effects of genotoxic carcinogens.</p>","PeriodicalId":8353,"journal":{"name":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","volume":"20 ","pages":"321-30"},"PeriodicalIF":0.0000,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"17","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-642-46856-8_29","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 17
Abstract
Two transgenic in vivo mutation assays are described which are based on LacZ (Muta Mouse) and LacI (Big Blue) shuttle vector systems. Their utility has already been explored by a number of investigators including our laboratory. The evaluation of data derived from these assays confirm that they offer a practical method for studying mutagenic activity and mechanism in a wide range of tissues including those of the respiratory and gastrointestinal tract. Therefore, these transgenic mutation assays are valuable tools to assess the organotropic effects of genotoxic carcinogens.
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