Assignment of three human markers in chromosome 21q11 to mouse chromosome 16.

J Yu, Y Shen, S Tong, F T Kao
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引用次数: 1

Abstract

Three unique sequence microclones from human chromosome region 21q11 were assigned to mouse chromosome 16 using a mouse/Chinese hamster cell hybrid 96Az2 containing a single mouse chromosome 16. This comparative mapping provides further homology between human chromosome 21 and mouse chromosome 16 to include the very proximal portion of the long arm of human chromosome 21. Since this part of human chromosome 21 is associated with mental retardation in Down syndrome individuals, its homologous mouse region should also be included in the construction of mouse models for studying Down syndrome phenotypes including mental retardation.

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人类21q11染色体上的三个标记在小鼠16号染色体上的定位。
利用小鼠/中国仓鼠细胞杂交96Az2,将人类染色体21q11区的3个独特序列微克隆分配到小鼠16号染色体上。这一比较图谱进一步提供了人类21号染色体和小鼠16号染色体之间的同源性,包括人类21号染色体长臂的非常近端部分。由于人类21号染色体的这一部分与唐氏综合征个体的智力发育迟缓有关,因此在构建研究包括智力发育迟缓在内的唐氏综合征表型的小鼠模型时,也应纳入其小鼠同源区域。
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