{"title":"Phenotypic differences between diabetes-prone BB rat sublines cosegregate with loci on chromosomes X and 10.","authors":"I Klöting, P Kovacs","doi":"10.1002/iub.7510450503","DOIUrl":null,"url":null,"abstract":"<p><p>BB rat sublines, all developing an insulin-dependent diabetes, differ in several phenotypic traits and in the genotype. To study the genetic basis of phenotypic differences diabetic BB/OK and BB/Mol rats characterized by significantly different frequency and age at onset of diabetes were reciprocally crossed. F1 females of both crosses were backcrossed onto diabetic BB/Mol rats resulting 94 BC1 hybrids which were analyzed for 30 polymorphic microsatellite markers on 14 chromosomes. For the first time it is shown that a diabetes protective locus on chromosome X and a gene around the D10Mit9 locus on chromosome 10 can explain the low frequency (ca. 50%) and the late age at onset of diabetes (ca. 130 days) in the BB/OK rat subline, respectively.</p>","PeriodicalId":8770,"journal":{"name":"Biochemistry and molecular biology international","volume":"45 5","pages":"865-70"},"PeriodicalIF":0.0000,"publicationDate":"1998-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/iub.7510450503","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry and molecular biology international","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/iub.7510450503","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
Abstract
BB rat sublines, all developing an insulin-dependent diabetes, differ in several phenotypic traits and in the genotype. To study the genetic basis of phenotypic differences diabetic BB/OK and BB/Mol rats characterized by significantly different frequency and age at onset of diabetes were reciprocally crossed. F1 females of both crosses were backcrossed onto diabetic BB/Mol rats resulting 94 BC1 hybrids which were analyzed for 30 polymorphic microsatellite markers on 14 chromosomes. For the first time it is shown that a diabetes protective locus on chromosome X and a gene around the D10Mit9 locus on chromosome 10 can explain the low frequency (ca. 50%) and the late age at onset of diabetes (ca. 130 days) in the BB/OK rat subline, respectively.
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