I Neira, L Poblete, P Porcille, P Silva, J Araya, J Bórquez, G Morales, L A Loyola, H Sagua
{"title":"[Activity of Dipernoids isolated from Azorella compacta (Llareta) on Trypanosoma cruzi amastigotes].","authors":"I Neira, L Poblete, P Porcille, P Silva, J Araya, J Bórquez, G Morales, L A Loyola, H Sagua","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The trypanocidad activity against amastigote forms of SPA-14, Tulahuen and G strains and CL Brener clone of Trypanosoma cruzi of diterpenoids isolated from Azorella compacta, Phil. (Llareta), a plant with ethnomedicinal prestige from prespanish age, was investigated. Amastigocidal activity was shown in azorellanol (2), diterpene isolated by first time, with an inhibitory concentration 50 (IC50) that varied between 60 M (CL Brener clone) and 84 M (SPA-14 strain), and in mulin -11,13 -dien-20-oico acid (5) with IC50 between 41 microM (G strain) and 87 mM (CL Brener clone). The cytotoxicity levels of both compounds against Hela and Vero cells and macrophages J144 are lower than nifurtimox and similar to gentian violet.</p>","PeriodicalId":75607,"journal":{"name":"Boletin chileno de parasitologia","volume":"53 1-2","pages":"9-13"},"PeriodicalIF":0.0000,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Boletin chileno de parasitologia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The trypanocidad activity against amastigote forms of SPA-14, Tulahuen and G strains and CL Brener clone of Trypanosoma cruzi of diterpenoids isolated from Azorella compacta, Phil. (Llareta), a plant with ethnomedicinal prestige from prespanish age, was investigated. Amastigocidal activity was shown in azorellanol (2), diterpene isolated by first time, with an inhibitory concentration 50 (IC50) that varied between 60 M (CL Brener clone) and 84 M (SPA-14 strain), and in mulin -11,13 -dien-20-oico acid (5) with IC50 between 41 microM (G strain) and 87 mM (CL Brener clone). The cytotoxicity levels of both compounds against Hela and Vero cells and macrophages J144 are lower than nifurtimox and similar to gentian violet.
研究了从紧斑小蠊中分离的二萜类化合物对克氏锥虫SPA-14、Tulahuen、G菌株和clbrener克隆的无尾线虫的抗虫活性。研究了一种自西班牙前时代起就具有民族药用价值的植物(Llareta)。首次分离到的二萜氮杂松香醇(2)的抑菌浓度50 (IC50)在60 μ M (CL Brener克隆)和84 μ M (pa -14菌株)之间，mulin -11,13 -dien-20-oico酸(5)的IC50在41 μ M (G菌株)和87 μ M (CL Brener克隆)之间。两种化合物对Hela和Vero细胞以及巨噬细胞J144的细胞毒性水平均低于硝呋替莫，与龙胆紫相似。
分享
京公网安备 11010802042870号
京ICP备2023020795号-1
求助内容：
应助结果提醒方式：
扫码关注我们
