Brain electrical source analysis of primary cortical components of the tibial nerve somatosensory evoked potential using regional sources

Abstract

Tibial nerve somatosensory evoked potentials (SEPs) show higher amplitudes ipsilateral to the side of stimulation, whereas subdural recordings revealed a source in the foot area of the contralateral hemisphere. We now investigated this paradoxical lateralization by performing a brain electrical source analysis in the P40 time window (34–46 ms). The tibial nerve was stimulated behind the ankle (8 subjects). On each side, 2048 stimuli were applied twice. SEPs were recorded using 32 magnetic resonance imaging (MRI)-verified electrode positions (bandpass 0.5–500 Hz). In each case, the P40 amplitude was higher ipsilaterally (0.45±0.14 μV) than contralaterally (−0.49±0.16 μV). The best fitting regional source, however, was always located in the contralateral hemisphere with a mean distance of 8.2±4.3 mm from the midline. The positivity pointed ipsilaterally shifting from a frontal orientation (P37) to a parietal direction (P40). The P40 dipole moment was 2.5 times stronger than the dipole moment of P37, which makes P40 most prominent in EEG recordings. However, with its oblique dipole orientation compared to the tangential P37 dipole, it is systematically underestimated in MEG. Dipole orientations explained interindividual variability of scalp potential distribution. SEP amplitudes were smaller when generated in the dominant (left) hemisphere. This is explained by deeper located sources (5.4±1.6 mm) with a more tangential orientation (Δϑ=17.5±2.3°) in the left hemisphere.