Viral vectors for veterinary vaccines.

M Sheppard
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Abstract

Whatever strategy is adopted for the development of viral vectors for delivery of veterinary vaccines there are several key points to consider: (1) Will the vectored vaccine give a delivery advantage compared to what's already available? (2) Will the vectored vaccine give a manufacturing advantage compared to what's already available? (3) Will the vectored vaccine provide improved safety compared to what's already available? (5) Will the vectored vaccine increase the duration of immunity compared to what's already available? (6) Will the vectored vaccine be more convenient to store compared to what's already available? (7) Is the vectored vaccine compatible with other vaccines? If there is no other alternative available then the answer to these questions is easy. However, if there are alternative vaccines available then the answers to these questions become very important because the answers will determine whether a vectored vaccine is merely a good laboratory idea or a successful vaccine.

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兽用疫苗病毒载体。
无论采用何种策略开发用于递送兽用疫苗的病毒载体,都有几个关键点需要考虑:(1) 与现有疫苗相比,载体疫苗是否具有递送优势?(2) 与现有疫苗相比,带载体疫苗是否具有生产优势?(3) 与现有疫苗相比,接种疫苗是否能提高安全性?(5) 与现有疫苗相比,有载体疫苗是否能延长免疫持续时间?(6) 与现有疫苗相比,接种疫苗是否更便于储存?(7) 疫苗是否与其他疫苗兼容?如果没有其他替代品,那么这些问题的答案就很简单。但是,如果有其他疫苗可供选择,那么这些问题的答案就变得非常重要,因为这些答案将决定带菌疫苗仅仅是一个好的实验室想法还是一种成功的疫苗。
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