Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy.

Journal of human virology Pub Date : 1998-03-01

M L Calabrò, J Sheldon, A Favero, G R Simpson, J R Fiore, E Gomes, G Angarano, L Chieco-Bianchi, T F Schulz

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Abstract

Objective: To study the seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV-8) in 779 Italian blood donors.

Study design/methods: Sera were tested for antibodies to a latency-associated nuclear antigen (LANA) and a capsid related protein encoded by ORF65.

Results: Among all Italian donors, 17.7% and 18.7% had antibodies to LANA and ORF65 protein, respectively, and 24.1% had antibodies to at least one antigen. KSHV/HHV-8 seroprevalence was higher in the Po valley and in Sardinia than close to the sub-Alpine Veneto region, Tuscany, or Apulia. KSHV/HHV-8 seroprevalence was almost equally distributed between men and women but increased in the older age groups.

Conclusions: The regional differences and age distribution in seroprevalence agree partially with the incidence of classic KS in Italy. The rarity of classic KS in KSHV/HHV-8-infected subjects and the equal gender distribution of seroprevalence suggest that other cofactors may contribute to KS development in human immunodeficiency virus type 1 (HIV-1)-uninfected individuals.

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意大利几个地区卡波西肉瘤相关疱疹病毒/人类疱疹病毒8的血清患病率

目的:研究意大利779名献血者卡波西肉瘤相关疱疹病毒/人疱疹病毒8型(KSHV/HHV-8)的血清阳性率。研究设计/方法:检测血清中潜伏相关核抗原(LANA)和ORF65编码的衣壳相关蛋白的抗体。结果:在所有意大利献血者中，分别有17.7%和18.7%的人有LANA和ORF65蛋白抗体，24.1%的人有至少一种抗原抗体。波河流域和撒丁岛的KSHV/HHV-8血清阳性率高于靠近亚阿尔卑斯威尼托地区、托斯卡纳或阿普利亚的地区。KSHV/HHV-8的血清患病率在男性和女性之间分布几乎相等，但在老年群体中有所增加。结论:意大利典型性KS血清患病率的地区差异和年龄分布与典型性KS发病率有部分一致。KSHV/ hhv -8感染受试者中经典KS的罕见性和血清阳性率的性别平等分布表明，其他辅助因素可能有助于人类免疫缺陷病毒1型(HIV-1)未感染个体中KS的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of human virology

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