{"title":"Molecular analysis of GB virus C/hepatitis G virus in HIV-1-positive intravenous drug users in Belgium.","authors":"H F Liu, E Goderniaux, G Burtonboy, P Goubau","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>A high prevalence of GB virus C (GBV-C)/hepatitis G virus (HGV) RNA and E2 antibodies is observable in human immunodeficiency virus type 1 (HIV-1)-infected individuals in Belgium, including intravenous drug users (IDUs), in whom the highest prevalence is observed. A molecular analysis of GBV-C/HGV could give indications on the origin of this infection in IDUs.</p><p><strong>Methods: </strong>We directly sequenced 7 GBV-C/HGV isolates from this IDU population and performed a phylogenetic analysis comparing the results to known GBV-C/HGV sequences.</p><p><strong>Results: </strong>All 7 isolates were GBV-C/HGV genome type 2. Three were found to be subtype 2a, and 4 belonged to the 2b subtype. No specific clustering was observed for strains obtained from IDUs in Belgium, and they were interspersed between other sequences with long branch lengths.</p><p><strong>Conclusion: </strong>Based on our results, it is unlikely that the IDUs were infected recently by GBV-C/HGV from a common ancestral virus.</p>","PeriodicalId":80032,"journal":{"name":"Journal of human virology","volume":"2 2","pages":"115-20"},"PeriodicalIF":0.0000,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of human virology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: A high prevalence of GB virus C (GBV-C)/hepatitis G virus (HGV) RNA and E2 antibodies is observable in human immunodeficiency virus type 1 (HIV-1)-infected individuals in Belgium, including intravenous drug users (IDUs), in whom the highest prevalence is observed. A molecular analysis of GBV-C/HGV could give indications on the origin of this infection in IDUs.
Methods: We directly sequenced 7 GBV-C/HGV isolates from this IDU population and performed a phylogenetic analysis comparing the results to known GBV-C/HGV sequences.
Results: All 7 isolates were GBV-C/HGV genome type 2. Three were found to be subtype 2a, and 4 belonged to the 2b subtype. No specific clustering was observed for strains obtained from IDUs in Belgium, and they were interspersed between other sequences with long branch lengths.
Conclusion: Based on our results, it is unlikely that the IDUs were infected recently by GBV-C/HGV from a common ancestral virus.
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