Protirelin (thyrotropin-releasing hormone) in thyroid gland: possible involvement in regulation of thyroid status.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-04-01

D G Smyth, J del Rio-Garcia, H Wallnöfer, H Gogl, W Simma, A Huber, R Embacher, H Fraser, G Kreil

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Abstract

Aim: To establish the presence of the hypothalamic hormone protirelin (thyrotropin-releasing hormone, TRH) in human thyroid and to investigate whether the concentration of this peptide in the thyroid gland is sensitive to thyroid status.

Methods: A procedure has been developed for the determination of TRH in the thyroid gland, distinct from TRH-like peptides which also react with TRH-antibody.

Results: Human thyroid was shown to contain both authentic TRH and TRH-like peptides, a similar pattern was seen in a range of animal thyroids. The concentrations of TRH in non-active goiter thyroids were substantial (41.6-248 pmol.g-1); in contrast the thyroids from hyperthyroid patients contained very little TRH (0.01-2.52 pmol.g-1).

Conclusion: The physiologic role of TRH in the thyroid is not known but the large difference between the concentrations of this hormone in non-active and hyperactive thyroids suggests that thyroidal TRH may be involved in the regulation of thyroid status.

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甲状腺中的促甲状腺素释放激素:可能参与甲状腺状态的调节。

目的:建立人甲状腺中下丘脑激素促甲状腺素释放激素(TRH)的存在，并探讨该肽在甲状腺中的浓度是否对甲状腺状态敏感。方法:开发了一种方法来测定甲状腺中的TRH，与TRH样肽不同，TRH样肽也与TRH抗体反应。结果:人类甲状腺被证明含有真正的TRH和TRH样肽，在一系列动物甲状腺中也发现了类似的模式。非活动性甲状腺肿甲状腺中TRH浓度较高(41.6 ~ 248pmol .g-1);而甲状腺功能亢进患者甲状腺中TRH含量极低(0.01-2.52 pmol.g-1)。结论:TRH在甲状腺中的生理作用尚不清楚，但该激素在非活跃和亢进甲状腺中的浓度差异较大，提示甲状腺TRH可能参与甲状腺状态的调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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