{"title":"Effects of 7-nitroindazole on long-term potentiation induced by l-clausenamide and high-frequency stimulation in rat hippocampus in vivo.","authors":"M R Zhao, J T Zhang","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To study the antagonistic effect of selective neuronal nitric-oxide synthase (nNOS) inhibitor 7-nitroindazole on the long-term potentiation (LTP) induced by l-clausenamide (Cla) in rat hippocampus in vivo.</p><p><strong>Methods: </strong>Population spike (PS) of evoked potentials was determined by extracellular recording technique in the hippocampal dentate gyrus (DG) of anesthetized rats.</p><p><strong>Results: </strong>7-Nitroindazole 2 nmol icv blocked the induction of LTP elicited by high-frequency (100 Hz) stimulation or Cla 5 nmol icv (P < 0.01), and L-arginine 225 mg.kg-1 i.p. prevented the action of 7-nitroindazole (P < 0.01).</p><p><strong>Conclusion: </strong>Nitric oxide produced by nNOS plays a role in the induction of Cla-induced LTP in hippocampus.</p>","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: To study the antagonistic effect of selective neuronal nitric-oxide synthase (nNOS) inhibitor 7-nitroindazole on the long-term potentiation (LTP) induced by l-clausenamide (Cla) in rat hippocampus in vivo.
Methods: Population spike (PS) of evoked potentials was determined by extracellular recording technique in the hippocampal dentate gyrus (DG) of anesthetized rats.
Results: 7-Nitroindazole 2 nmol icv blocked the induction of LTP elicited by high-frequency (100 Hz) stimulation or Cla 5 nmol icv (P < 0.01), and L-arginine 225 mg.kg-1 i.p. prevented the action of 7-nitroindazole (P < 0.01).
Conclusion: Nitric oxide produced by nNOS plays a role in the induction of Cla-induced LTP in hippocampus.
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