Oxygen-independent microbicidal mechanisms of phagocytes.

T Ganz
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引用次数: 33

Abstract

The principal biological function of phagocytic cells is the destruction of invading microorganisms. Following phagocytosis, microbes are exposed to multiple antimicrobial substances ranging in complexity from simple oxygen radicals to large proteins. These substances disrupt various microbial structures and eventually kill and digest most of the invaders. This review is focused on oxygen-independent microbicidal mechanisms in granulocytes and macrophages.

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吞噬细胞不依赖氧的杀微生物机制。
吞噬细胞的主要生物学功能是消灭入侵的微生物。在吞噬作用之后,微生物暴露于多种抗菌物质中,从简单的氧自由基到大的蛋白质。这些物质破坏各种微生物结构,最终杀死并消化大部分入侵者。本文综述了粒细胞和巨噬细胞中不依赖氧的杀微生物机制。
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