Effects of glycyrrhizae and glycyrrhizic acid on cellular immunocompetence in low-dose gamma-ray irradiated mice.

Changgeng yi xue za zhi Pub Date : 1999-09-01

I H Lin, D M Hau, J S You, H F Huang, K T Chen, Y Y Chiou

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Abstract

Background: For both animals and human beings, it is important to prevent damage from ionizing radiation and to restore immunocompetence following irradiation. The present study was conducted to investigate the effects of glycyrrhizae (GL) and glycyrrhetinic acid (GA) on cellular immunocompetence in low dose gamma-ray-irradiated mice.

Methods: Six- to 8-week-old ICR strain' Crl:CD-1-ICR (BR) strain male mice, bred in the Institute of Cancer Research, U.S.A., were chosen and divided into four groups. Group A was the normal control. Group B, the experimental control, received 1 Gy of whole body gamma-ray irradiation. Groups C and D, the experimental groups, were treated with 500 mg/kg of GL (orally) and 5 mg/kg body weight of GA (i.p.), respectively, once a day, 5 days a week for 2 weeks after gamma-irradiation. The tested mice were killed, at 6 different intervals to measure their leukocyte and differential counts. Cellular immunocompetence was measured by the 3H-thymidine uptake in each group.

Results: One gray of gamma-ray irradiation had evident inhibition on the leukocyte and differential counts and the cellular immunity of mice. GL and GA could help to restore the decreased leukocyte counts and the cellular immunocompetence in low dose gamma-irradiated mice.

Conclusion: GL and GA could help to restore decreased leukocyte counts and the cellular immunocompetence in low-dose gamma-ray-irradiated mice.

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甘草和甘草酸对低剂量γ射线照射小鼠细胞免疫能力的影响。

背景:对动物和人类来说，预防电离辐射损伤和恢复辐射后的免疫能力都是很重要的。本研究探讨了甘草酸和甘草次酸对低剂量γ射线照射小鼠细胞免疫能力的影响。方法:选取美国癌症研究所繁殖的6 ~ 8周龄ICR株“Crl:CD-1-ICR (BR)”雄性小鼠，分为4组。A组为正常对照组。B组为实验对照组，接受1 Gy的全身γ射线照射。试验组C组和D组分别给予500 mg/kg GL(口服)和5 mg/kg体重GA (i.p.)，每日1次，每周5天，连续2周。实验小鼠在6个不同的时间间隔被杀死，以测量它们的白细胞和差异计数。采用3h -胸腺嘧啶摄取法测定各组细胞免疫能力。结果:γ射线辐照对小鼠的白细胞、白细胞计数和细胞免疫均有明显的抑制作用。GL和GA对低剂量γ辐照小鼠的白细胞计数和细胞免疫功能有一定的恢复作用。结论:GL和GA对低剂量γ射线照射小鼠的白细胞计数和细胞免疫功能有一定的恢复作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Changgeng yi xue za zhi

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