Microwaves and cellular immunity

Bioelectrochemistry and bioenergetics (Lausanne, Switzerland) Pub Date : 1999-10-01 DOI:10.1016/S0302-4598(99)00058-6

E.E Fesenko , V.R Makar , E.G Novoselova , V.B Sadovnikov

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引用次数: 61

Abstract

Whole body microwave sinusoidal irradiation of male NMRI mice with 8.15–18 GHz (1 Hz within) at a power density of 1 μW/cm² caused a significant enhancement of TNF production in peritoneal macrophages and splenic T lymphocytes. Microwave radiation affected T cells, facilitating their capacity to proliferate in response to mitogenic stimulation. The exposure duration necessary for the stimulation of cellular immunity ranged from 5 h to 3 days. Chronic irradiation of mice for 7 days produced the decreasing of TNF production in peritoneal macrophages. The exposure of mice for 24 h increased the TNF production and immune proliferative response, and these stimulatory effects persisted over 3 days after the termination of exposure. Microwave treatment increased the endogenously produced TNF more effectively than did lipopolysaccharide, one of the most potential stimuli of synthesis of this cytokine. The role of microwaves as a factor interfering with the process of cell immunity is discussed.

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微波和细胞免疫

功率密度为1 μW/cm2, 8.15 ~ 18 GHz (1 Hz内)对雄性NMRI小鼠进行全身微波正弦照射，可显著增强腹腔巨噬细胞和脾脏T淋巴细胞的TNF生成。微波辐射影响T细胞，促进其增殖能力，以响应有丝分裂刺激。刺激细胞免疫所需的暴露时间从5小时到3天不等。慢性照射小鼠7 d后，腹腔巨噬细胞产生TNF降低。小鼠暴露24小时可增加TNF的产生和免疫增殖反应，这些刺激作用在暴露终止后持续3天。微波处理比脂多糖更有效地增加内源性产生的TNF，脂多糖是合成该细胞因子的最潜在刺激之一。讨论了微波作为干扰细胞免疫过程的因素所起的作用。

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Bioelectrochemistry and bioenergetics (Lausanne, Switzerland)

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