{"title":"Effect of acute and chronic administration of sodium valproate on lipid peroxidation and antioxidant system in rat liver.","authors":"S Seçkin, C Başaran-Küçükgergin, M Uysal","doi":"10.1111/j.1600-0773.1999.tb02025.x","DOIUrl":null,"url":null,"abstract":"<p><p>Changes in glutathione and lipid peroxide levels as well as in the activities of superoxide dismutase, glutathione peroxidase, catalase and glutathione-S-transferase have been studied in rats after acute and chronic sodium valproate treatments. Glutathione levels were decreased only after acute sodium valproate treatment. Neither acute nor chronic treatment influenced lipid peroxidation but induced glutathione-S-transferase activity significantly. On the other hand, no alterations in glutathione peroxidase and superoxide dismutase activities were found, except slight induction of catalase activity after acute administration of sodium valproate. These results indicate that sodium valproate treatment did not induce oxidative stress in the liver.</p>","PeriodicalId":19876,"journal":{"name":"Pharmacology & toxicology","volume":"85 6","pages":"294-8"},"PeriodicalIF":0.0000,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0773.1999.tb02025.x","citationCount":"33","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacology & toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1600-0773.1999.tb02025.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 33
Abstract
Changes in glutathione and lipid peroxide levels as well as in the activities of superoxide dismutase, glutathione peroxidase, catalase and glutathione-S-transferase have been studied in rats after acute and chronic sodium valproate treatments. Glutathione levels were decreased only after acute sodium valproate treatment. Neither acute nor chronic treatment influenced lipid peroxidation but induced glutathione-S-transferase activity significantly. On the other hand, no alterations in glutathione peroxidase and superoxide dismutase activities were found, except slight induction of catalase activity after acute administration of sodium valproate. These results indicate that sodium valproate treatment did not induce oxidative stress in the liver.
研究了大鼠急性和慢性丙戊酸钠治疗后谷胱甘肽和脂质过氧化物水平以及超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶和谷胱甘肽s -转移酶活性的变化。谷胱甘肽水平仅在急性丙戊酸钠治疗后降低。急性和慢性治疗均不影响脂质过氧化，但显著诱导谷胱甘肽- s -转移酶活性。另一方面，除了急性丙戊酸钠对过氧化氢酶活性有轻微的诱导外，谷胱甘肽过氧化物酶和超氧化物歧化酶活性没有变化。这些结果表明丙戊酸钠治疗不会引起肝脏氧化应激。
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