Further studies on chromocentres and their implications in regeneration.

Abstract

Previous investigations using a number of invertebrates, as well as regenerative tissues/organs of various vertebrates, have promulgated the hypothesis that heterochromatin, in the form of nuclear chromocentres, is correlated with the ability to regenerate. In order to test the universality of this hypothesis, cells from a variety of additional animals were examined for the presence of nuclear chromocentres. In accordance with the hypothesis, cells from these organisms contained numerous chromocentres. Evidence indicates that chromocentres, double minute chromosomes, chromosome 'dots', and telomeres may be different forms of the same heterochromatin entity.