Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland.

K Ofuji, M Satake, T McMahon, J Silke, K J James, H Naoki, Y Oshima, T Yasumoto
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引用次数: 212

Abstract

Two new analogs of azaspiracid, azaspiracid-2 and azaspiracid-3, were isolated from mussels collected at Arranmore Island, Ireland in 1997 as additional causes of human intoxication. Their structures were determined to be 8-methylazaspiracid and 22-demethylazaspiracid, respectively by NMR and negative ion FAB CID MS/MS experiments.

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从贻贝(Mytilus edulis)中分离出的两种氮唑酸类似物,在爱尔兰引起人类中毒。
1997年在爱尔兰阿兰莫尔岛收集的贻贝中分离出两种新的氮氮吡嗪酸类似物,氮氮吡嗪酸-2和氮氮吡嗪酸-3,作为人类中毒的额外原因。通过核磁共振和负离子FAB - CID MS/MS实验确定了它们的结构分别为8-甲基lazasacid和22-去甲基lazasacid。
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Erratum: Alfonso D, Johnson HA, Colman-Saizarbitoria T, Presley CP, McCabe GP, McLaughlin JL (1996): SARs of annonaceous acetogenins in rat liver mitochondria. Nat Toxins 4:181-188. Advances in detection methods for fungal and algal toxins. HPLC/MS analysis of fusarium mycotoxins, fumonisins and deoxynivalenol. Neuronal binding of tetanus toxin compared to its ganglioside binding fragment (H(c)). A new type sandwich immunoassay for microcystin: production of monoclonal antibodies specific to the immune complex formed by microcystin and an anti-microcystin monoclonal antibody.
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