Bronchodilating effects of bambuterol on bronchoconstriction in guinea pigs.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-07-01

Q M Xie, L H Zeng, Y X Zheng, Y B Lu, Q H Yang

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Abstract

Aim: To study the effects of bambuterol (Bam) on bronchoconstriction in guinea pigs.

Methods: Bronchospasm induced by histamine aerosol, lung resistance (RL) and dynamic lung compliance (Cdyn) changes induced by ovalbumin aerosol in vivo, isolated resting lung parenchyma strips, and carbamylcholine-induced tracheal constriction in vitro in guinea pig were investigated.

Results: Bam dose-dependently prolonged the time to histamine-induced collapse, ED50 values (95% confidence limits) of Bam intragastric gavage (i.g.) after 1 h, 4 h, and 24 h were 0.74 (0.60-0.91), 0.75 (0.61-0.91) and 1.00 (0.77-1.30) mg.kg-1, respectively. Bam 2 or 10 mg.kg-1 i.g. 2 h before ovalbumin aerosol partly or almost completely inhibited bronchial challenge of ovalbumin-induced change of RL and Cdyn. Bam 0.1-1.0 mumol.L-1 gave a weak relaxation on isolated tracheal strips induced by carbamylcholine and failed to relax the isolated resting lung parenchyma strips in guinea pig.

Conclusion: Bam showed a long-acting bronchodilation by its slow metabolism in vivo.

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班特罗对豚鼠支气管收缩的支气管扩张作用。

目的:研究班布特罗(Bam)对豚鼠支气管收缩的影响。方法:观察组胺气雾剂致豚鼠支气管痉挛、卵清蛋白气雾剂致豚鼠肺阻力(RL)和肺动态顺应性(Cdyn)的变化、离体静息肺实质条及氨甲酰胆碱致离体气管收缩。结果:Bam剂量依赖性地延长了组胺诱导的崩溃时间，Bam灌胃(ig) 1 h、4 h和24 h的ED50值(95%置信限)分别为0.74(0.60-0.91)、0.75(0.61-0.91)和1.00 (0.77-1.30)mg。公斤,分别。Bam 2或10毫克。kg-1在卵清蛋白雾化前2小时ig部分或几乎完全抑制卵清蛋白引起的RL和Cdyn变化的支气管挑战。Bam 0.1-1.0 mumol。L-1对氨甲酰胆碱诱导的离体豚鼠气管条有弱松弛作用，对离体静息肺实质条无松弛作用。结论:Bam体内代谢缓慢，具有长效支气管扩张作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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