Water-retention effect of suberogorgin was due to secretion of antidiuretic hormone in rat.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

W D Peng

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Abstract

Aim: To study the mechanism of antidiuretic effect of suberogorgin (Sub).

Methods: Conscious rat was given i.g. Sub 3.16 mg.kg-1 20 min after water-loaded treatment and then urine was collected in metabolic cage. Ion excretion was determined in atomic emission spectrometry. Urinary prostaglandin E (PGE), plasma PGE, antidiuretic hormone (ADH), and aldosterone were measured with RIA. Sub vs pituitrin or DOCA effects were carried out in hypophysectomized or adrenalectomized rats.

Results: The urine volume and the excretions of urinary sodium and potassium were decreased, maximally by 91%, 76%, and 86%, during the 24-h period after Sub. This antidiuretic effect possessed a progressive weakening with time. The concentrations of urinary PGE, plasma PGE, and ADH were increased by 25%, 212%, and 538%, respectively, but plasma aldosterone was not significantly influenced, 2 h after Sub dosing. The response of urine-excretion of rat to Sub was almost resisted by hypophysectomy but not by adrenalectomy.

Conclusion: Sub decreased the urine excretion by, at least in part, accelerating the secretion of ADH but neither by PGE nor by aldosterone.

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牛皮甙的保水作用主要是由于其在大鼠体内分泌抗利尿激素所致。

目的:研究牛皮素的抗利尿作用机制。方法:清醒大鼠灌胃3.16 mg。补水20 min后取Kg-1，然后在代谢笼中收集尿液。离子排泄用原子发射光谱法测定。采用RIA法测定尿前列腺素E (PGE)、血浆PGE、抗利尿激素(ADH)、醛固酮水平。在去垂体或去肾上腺的大鼠中观察垂体后叶素和DOCA的作用。结果:尿量和尿钠、尿钾排泄量在治疗后24h内下降幅度最大，分别为91%、76%和86%，抗利尿作用随时间逐渐减弱。亚给药2 h后，尿PGE、血浆PGE和ADH浓度分别升高25%、212%和538%，但血浆醛固酮未受显著影响。大鼠尿排泄对Sub的反应几乎被垂体切除术所抑制，而肾上腺切除术则没有。结论:亚胺至少部分通过加速ADH分泌来减少尿量，但对PGE和醛固酮均无作用。

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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