Determination of the prevalence of fibrinogen Banks peninsula mutation (gamma280Tyr-->Cys) by PCR.

Abstract

A mutation of Tyr-->Cys at position 280 of the gamma chain of fibrinogen was recently determined to be the cause for fibrinogen Banks peninsula. A novel polymerase chain reaction/restriction digestion assay for this mutation was developed and used for the screening of 300 apparently healthy European blood donors. None of these subjects carried the mutation.