Treatment with mycophenolate mofetil attenuates the development of Heymann nephritis.

M E Luca, L C Paul, A M van Der Wal, J A Bruijn, E de Heer
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引用次数: 9

Abstract

Active Heymann nephritis in the rat is a model of idiopathic membranous glomerulopathy in man. The autoimmune response is directed to gp330, a large epithelial glycoprotein that is expressed on the tubular and the glomerular epithelium. Characteristic of the disease is the presence of immune complexes and complement in the glomerulus and proteinuria. We studied the effect of a new xenobiotic immunosuppressive agent, mycophenolate mofetil, on active Heymann nephritis. Mycophenolate mofetil significantly reduced the production of autoantibodies against gp330 in rats with Heymann nephritis. Glomerular deposition of IgG was not significantly lower in the treated groups than in the untreated groups with active Heymann nephritis, as detected by immunofluorescence staining. Glomerular complement component C3, however, was significantly lower in the mycophenolate mofetil treated rats. Treatment did not completely prevent the disease, but the percentage of rats that developed proteinuria in the treated groups was significantly lower than in untreated Heymann rats. The results of this study show that mycophenolate mofetil influences the T-cell-mediated humoral autoimmune response in active Heymann nephritis and results in a decreased severity of the disease.

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霉酚酸酯治疗可减轻海曼肾炎的发展。
大鼠活动性海曼肾炎是人类特发性膜性肾小球病的模型。自身免疫反应指向gp330,这是一种在肾小管上皮和肾小球上皮上表达的大的上皮糖蛋白。本病的特点是肾小球中存在免疫复合物和补体以及蛋白尿。我们研究了一种新的异种免疫抑制剂霉酚酸酯对活动性海曼肾炎的作用。霉酚酸酯显著降低海曼肾炎大鼠抗gp330自身抗体的产生。免疫荧光染色检测,治疗组活动性海曼肾炎的肾小球IgG沉积不明显低于未治疗组。然而,在霉酚酸酯治疗的大鼠中,肾小球补体成分C3明显降低。治疗并没有完全预防疾病,但治疗组发生蛋白尿的大鼠比例明显低于未治疗的海曼大鼠。本研究结果表明,霉酚酸酯影响活动性海曼肾炎中t细胞介导的体液自身免疫反应,并导致疾病严重程度降低。
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