Maximum effect of urokinase plasminogen activator inhibitors in the control of invasion and metastasis of rat mammary cancer.

D M Evans, K D Sloan-Stakleff
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引用次数: 18

Abstract

Experimentally induced pulmonary metastases of mammary cancer in the Fisher 344 rat can be suppressed by the inhibition of urokinase plasminogen activator (uPA). The inhibition of uPA with amiloride or B428 has been shown to be dose dependent. Increased dosage levels of inhibitors might be expected to enhance levels of suppression of metastases. The use of each of these inhibitors at equipotent concentrations that exceeded the doses administered in previous studies failed to eliminate pulmonary metastases. These results demonstrate that a maximum limit is attained for the inhibitory capacities on cells during in vitro invasion or in vivo metastasis. At increased levels, uPA inhibitors continue to suppress, but do not eradicate, experimental pulmonary metastases of MATB cell rat mammary cancer.

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尿激酶纤溶酶原激活物抑制剂在控制大鼠乳腺癌侵袭转移中的最大作用。
抑制尿激酶纤溶酶原激活物(uPA)可抑制Fisher 344大鼠实验性诱导的乳腺癌肺转移。阿米洛利或B428对uPA的抑制已被证明是剂量依赖性的。增加抑制剂的剂量水平可能会提高对转移的抑制水平。这些抑制剂在同等浓度下的使用,超过了先前研究中给予的剂量,未能消除肺转移。这些结果表明,在体外侵袭或体内转移过程中,对细胞的抑制能力达到了最大限度。在水平升高时,uPA抑制剂继续抑制,但不能根除MATB细胞大鼠乳腺癌的实验性肺转移。
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