Prenatal X-irradiation increases GFAP- and calbindin D28k-immunoreactivity in the medial subdivision of the nucleus of solitary tract in the rat

Journal of the autonomic nervous system Pub Date : 2000-04-12 DOI:10.1016/S0165-1838(99)00085-5

Thierry D. Jacquin , Qiang Xie , Takanori Miki , Irawan Satriotomo , Masahiro Itoh , Yoshiki Takeuchi

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引用次数: 7

Abstract

Glial fibrillary acidic protein- (GFAP) and calbindin D28k-immunoreactivity (IR) were investigated in the medial subdivision of the nucleus of the solitary tract (mNST) of prenatally X-irradiated rats. Pregnant rats were exposed to a single whole-body X-irradiation on day 11 or 16 of gestation at a dose of 1.3 Gy. The offspring were killed at 7–14 days of age for the immunohistochemical observations. Rat pups showed strong GFAP-IR at the level rostral to the obex when receiving X-rays on day 11 of gestation, with hypertrophy of astrocyte cell bodies and cytoplasmic processes, but weak GFAP-IR when receiving X-rays on day 16 of gestation. Calbindin D28k-IR was stronger in the animals receiving X-rays on day 11 or 16 of gestation compared to that in the control animals. In the present study, the increase of GFAP- and calbindin D28k-IR cells in the mNST might indicate that adaptative mechanisms are taking place to preserve integrated nervous system function and possibly, to provide neuroprotection.

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产前x射线照射可提高大鼠孤立束核内侧亚区GFAP-和calbindin d28k的免疫反应性

研究了x射线照射前大鼠孤立束核内侧亚区胶质纤维酸性蛋白(GFAP)和钙结合蛋白d28k的免疫反应性(IR)。怀孕大鼠在妊娠第11天或第16天接受单次全身x射线照射，剂量为1.3 Gy。于7 ~ 14日龄处死，进行免疫组化观察。妊娠第11天接受x射线照射时，大鼠幼崽在喙侧至臀部水平表现出较强的gmap - ir，星形胶质细胞体和细胞质增生，但妊娠第16天接受x射线照射时gmap - ir较弱。与对照动物相比，在妊娠第11或16天接受x光照射的动物体内Calbindin D28k-IR更强。在本研究中，mst中GFAP-和calbindin D28k-IR细胞的增加可能表明适应性机制正在发生，以维持综合神经系统功能，并可能提供神经保护。

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Journal of the autonomic nervous system

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