Overview of membrane transport.

Q4 Pharmacology, Toxicology and Pharmaceutics Pharmaceutical biotechnology Pub Date : 1999-01-01 DOI:10.1007/0-306-46812-3_1
D M Oh, G L Amidon
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引用次数: 9

Abstract

Pharmaceutical scientists increasingly utilize transporters for drug delivery and targeting. The biological barriers to drug delivery can basically be divided into epithelial, endothelial, elimination, and target cell barriers. Membrane transporters play an important role in drug entrance and exit from the body. In addition, it is possible to utilize transporters for drug delivery, e.g., improving oral absorption via the peptide transporter. Identification, a better understanding of their transport characteristics, and the regulation of the membrane transporters will allow the development of better drug delivery strategies.

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膜运输概述。
制药科学家越来越多地利用转运体来给药和靶向。药物传递的生物屏障基本可分为上皮细胞屏障、内皮细胞屏障、消除细胞屏障和靶细胞屏障。膜转运蛋白在药物进出体内发挥着重要作用。此外,还可以利用转运体进行药物递送,例如,通过肽转运体改善口服吸收。识别,更好地了解它们的运输特性,以及对膜转运蛋白的调节将有助于开发更好的药物递送策略。
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