[The effect of gamma-L-glutamyl histamine on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome p-450].

Voprosy meditsinskoi khimii Pub Date : 1999-11-01
V E Nebol'sin, V V Krzhechkovskaia, G A Zheltukhina, R P Evstigneeva, V L Kovaleva
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引用次数: 0

Abstract

gamma-L-Glutamyl-histamine (gamma-GluHA) was synthesized at Department of the chemistry and technology of fine organic compounds M. V. Lomonosov Moscow state academy of fine chemical technology. It was investigated the influence of gamma-L-glutamyl-histamine on the severity of experimental anaphylactic reaction, hormonal content in blood plasma and liver cytochrome P-450. The induction of liver cytochrome P-450, the elevation of hormonal content (thyroxine and glucocorticoids) in blood plasma and decrease of the severity of experimental anaphylactic reaction are observed.

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[γ - l -谷氨酰组胺对实验性过敏反应严重程度、激素状态及肝细胞色素p-450的影响]。
γ - l-谷氨酰胺组胺(γ - gluha)是在莫斯科国立精细化学技术学院精细有机化合物化学与技术部合成的。探讨γ - l-谷氨酰胺组胺对实验性过敏反应严重程度、血浆激素含量及肝细胞色素P-450的影响。观察到肝细胞色素P-450的诱导,血浆中激素(甲状腺素和糖皮质激素)含量的升高,实验过敏反应的严重程度降低。
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