Synthesis of enantiomerically pure C2-symmetric 4-pyrrolidinopyridine derivative as a chiral acyl transfer catalyst for the kinetic resolution of secondary alcohols

Abstract

The first chiral C2-symmetric 4-pyrrolidinopyridine (PPY) derivative was synthesized in an enantiomerically pure form and successfully utilized as a chiral nucleophilic catalyst for the kinetic resolution of secondary alcohols leaving one enantiomer with high selectivity factors (up to s = 13.5).