Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia.

Kidney international. Supplement Pub Date : 2000-04-01
L G Fine, D Bandyopadhay, J T Norman
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Abstract

The question of why chronic renal diseases progress is a topic only recently investigated. Putative causes such as proteinuria do not account for all aspects of progressive renal disease. An alternative mechanism, chronic hypoxia, is proposed that might better explain certain elements of progressive renal disease, but elements of the hypothesis remain subject to further study.

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除了蛋白尿之外,不同类型肾脏疾病的进展是否有共同的机制?迈向慢性缺氧的统一主题。
为什么慢性肾脏疾病进展的问题是最近才调查的一个话题。假定的病因如蛋白尿并不能解释进行性肾脏疾病的所有方面。另一种机制,慢性缺氧,被提出可能更好地解释进展性肾脏疾病的某些因素,但该假设的要素仍有待进一步研究。
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Alport syndrome. New strategies to prevent cardiovascular risk in chronic kidney disease. Proceedings of the Sixth International Conference on Hypertension and the Kidney. February 2008. Madrid, Spain. Prevention of Renal Disease in the Emerging World: Toward Global Health Equity. Proceedings of the Bellagio Conference, March 16-18, 2004, Italy. The in vitro biocompatibility performance of a 25 mmol/L bicarbonate/10 mmol/L lactate-buffered peritoneal dialysis fluid. Proceedings of the Third International Conference on Hypertension and the Kidney, February 2002, Madrid, Spain.
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