Evaluation of the Effect of Radiation Therapy to Nasopharyngeal Carcinoma by Positron Emission Tomography with 2-[F-18]Fluoro-2-deoxy-D-glucose

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-03-01 DOI:10.1016/S1095-0397(00)00039-X

Nan-Jing Peng MD , Sang-Hue Yen MD , Wen-Shan Liu MD , Daw-Guey Tsay MD , Ren-Shyan Liu MD

{"title":"Evaluation of the Effect of Radiation Therapy to Nasopharyngeal Carcinoma by Positron Emission Tomography with 2-[F-18]Fluoro-2-deoxy-D-glucose","authors":"Nan-Jing Peng MD , Sang-Hue Yen MD , Wen-Shan Liu MD , Daw-Guey Tsay MD , Ren-Shyan Liu MD","doi":"10.1016/S1095-0397(00)00039-X","DOIUrl":null,"url":null,"abstract":"<div>Purpose: This investigation evaluated the effectiveness of positron emission tomography with 2-[F-18]fluoro-2-deoxy-D-glucose (PET-FDG) in assessing residual tumor or tumor recurrence in postradiation nasopharyngeal carcinoma (NPC) patients.Procedures: Forty-six patients with histologically proven NPC who received radiotherapy were included. PET-FDG images were analyzed by a semiquantitative method, metabolic ratio (tumor to cerebellum ratio).Results: The overall sensitivity and specificity of PET-FDG to detect residual tumors and recurrent lesions in the postradiation patients were 80% (12/15) and 87% (27/31), respectively. In patients with PET-FDG 6 months after radiation therapy, the sensitivity and specificity raised to 92% (11/12) and 100% (20/20), respectively.Conclusions: PET-FDG is effective in the evaluation of NPC treated with radiation. The optimal timing in assessing residual tumor or tumor recurrence in postradiation patients should be 6 months or later.</div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 2","pages":"Pages 51-56"},"PeriodicalIF":0.0000,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00039-X","citationCount":"23","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S109503970000039X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 23

Abstract

Purpose: This investigation evaluated the effectiveness of positron emission tomography with 2-[F-18]fluoro-2-deoxy-D-glucose (PET-FDG) in assessing residual tumor or tumor recurrence in postradiation nasopharyngeal carcinoma (NPC) patients.

Procedures: Forty-six patients with histologically proven NPC who received radiotherapy were included. PET-FDG images were analyzed by a semiquantitative method, metabolic ratio (tumor to cerebellum ratio).

Results: The overall sensitivity and specificity of PET-FDG to detect residual tumors and recurrent lesions in the postradiation patients were 80% (12/15) and 87% (27/31), respectively. In patients with PET-FDG 6 months after radiation therapy, the sensitivity and specificity raised to 92% (11/12) and 100% (20/20), respectively.

Conclusions: PET-FDG is effective in the evaluation of NPC treated with radiation. The optimal timing in assessing residual tumor or tumor recurrence in postradiation patients should be 6 months or later.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

2-[F-18]氟-2-脱氧-d -葡萄糖正电子发射断层扫描评价鼻咽癌放疗效果

目的:评价2-[F-18]氟-2-脱氧-d -葡萄糖正电子发射断层扫描(PET-FDG)对鼻咽癌(NPC)术后残留肿瘤或肿瘤复发的评估效果。方法:纳入46例经组织学证实接受放疗的鼻咽癌患者。用半定量方法分析PET-FDG图像，代谢比(肿瘤与小脑的比值)。结果:PET-FDG对放疗后患者残留肿瘤和复发病变的总体敏感性为80%(12/15)，特异性为87%(27/31)。放疗后6个月PET-FDG患者的敏感性和特异性分别提高到92%(11/12)和100%(20/20)。结论:PET-FDG对鼻咽癌放射治疗的评价是有效的。评估放疗后患者肿瘤残留或肿瘤复发的最佳时机应为6个月或更晚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Clinical positron imaging : official journal of the Institute for Clinical P.E.T

自引率

0.00%

发文量