A conformational change in the Fc precludes the binding of two Fcγ receptor molecules to one IgG

Abstract

Recent NMR analyses of IgG–FcγR interactions in solution have identified the FcγR-binding site on the Fc region and provided evidence for a conformational change in the Fc occurring during the interaction. Here, Koichi Kato and colleagues discuss how this conformational change explains the incapacity of IgG molecules to trigger responses deleterious to the organism, in the absence of antigen cross-linking.