Biphasic calcium phosphates: influence of three synthesis parameters on the HA/beta-TCP ratio.

J M Bouler, R Z LeGeros, G Daculsi
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引用次数: 146

Abstract

Hydroxyapatite (HA) contents measurements were conducted on eight biphasic calcium phosphate (BCP) samples obtained by sintering calcium-deficient apatite formed previously by hydrolyzing a dicalcium phosphate dihydrate (DCPD) powder. We evaluated the influences and interactions of three synthesis factors: alkalinity, process duration, and concentration of the water suspension in DCPD. Those parameters were varied simultaneously between two limit levels. Experiments used a factorial design method (FDM) allowing optimization of the number of samples as well as statistical analysis of results. FDM showed that HA content, in a defined experimental area, can be described by a first-order polynomial equation in which the initial alcalinity and the DCPD/water ratio are the major influences. Experiment prove that pH measured at the end of the hydrolysis was predictive of the HA content in the final BCP. This study leads up to an isoresponse line diagram which will allow the synthesis of some BCP with fitted HA/beta-tricalcium phosphate ratios.

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双相磷酸钙:三个合成参数对HA/ β - tcp比的影响。
对8个双相磷酸钙(BCP)样品进行了羟基磷灰石(HA)含量测定,该样品是由磷酸二氢钙(DCPD)粉末水解形成的缺钙磷灰石烧结而成的。我们评估了三个合成因素的影响和相互作用:碱度、工艺时间和DCPD中水悬浮液的浓度。这些参数在两个极限水平之间同时变化。实验使用因子设计方法(FDM),允许优化样本数量以及结果的统计分析。FDM表明,在确定的实验区域内,HA含量可以用一阶多项式方程来描述,其中初始碱度和DCPD/水比是主要影响因素。实验证明,水解结束时测定的pH值可以预测最终BCP中HA的含量。这项研究导致了一个等响应线图,这将允许合成一些具有合适的HA/ β -磷酸三钙比例的BCP。
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