The skin barrier: analysis of physiologically important elements and trace elements.

B Forslind
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引用次数: 29

Abstract

Changes in the properties of the skin barrier should have correlates in the physiological status of the differentiating epidermal cells. However, the quantitative distributions of physiologically important elements and trace elements of the skin has been a neglected area of research for lack of tools to investigate this highly differentiated tissue. With the event of the particle probes, the electron microprobe and the scanning proton microprobe, it has become possible to investigate different aspects of normal skin physiology as well as pathophysiological processes. In addition penetration profiles of allergenic metals can be demonstrated with the trace element sensitive proton probe. Future approaches to the study of skin physiology in normal and pathological conditions should incorporate other techniques including immunological and biochemical tagging of particular cells to achieve a broad basis for interpretations of data.

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皮肤屏障:生理重要元素和微量元素的分析。
皮肤屏障特性的变化应该与表皮细胞分化的生理状态有关。然而,由于缺乏研究这种高度分化组织的工具,皮肤中重要生理元素和微量元素的定量分布一直是一个被忽视的研究领域。随着粒子探针、电子探针和扫描质子探针的出现,研究正常皮肤生理和病理生理过程的不同方面成为可能。此外,还可以用微量元素敏感质子探针证明致敏金属的渗透曲线。未来在正常和病理条件下研究皮肤生理学的方法应该结合其他技术,包括特定细胞的免疫学和生化标记,以实现对数据解释的广泛基础。
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