Immunological function of tubular epithelial cells: the functional implications of CD40 expression.

C van Kooten, A M Woltman, M R Daha
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引用次数: 32

Abstract

Tubulo-interstitial inflammation in the kidney is characterized by the presence of activated T cells. Both by the local production of cytokines, as well as by direct cell-cell interactions, these activated T cells might affect the immune and inflammatory response. Recently it has been demonstrated that these kidney-infiltrating T cells express CD40 ligand and that tubular epithelial cells (TECs) express CD40. In the present review we will discuss the potential implications of CD40-CD40L interactions for the activation of TECs and its immunological function.

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小管上皮细胞的免疫功能:CD40表达的功能意义。
肾小管间质炎症的特点是存在活化的T细胞。通过局部产生细胞因子,以及通过直接的细胞间相互作用,这些活化的T细胞可能影响免疫和炎症反应。最近有研究表明,这些肾浸润性T细胞表达CD40配体,而小管上皮细胞(tec)表达CD40。在本综述中,我们将讨论CD40-CD40L相互作用对TECs激活及其免疫功能的潜在影响。
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