The Origin of Antigenic Diversity in Plasmodium falciparum

Stephen M Rich , Marcelo Urbano Ferreira , Francisco J Ayala
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引用次数: 60

Abstract

Most studies of genetic variability of Plasmodium falciparum have focused on protein antigens and the genes that encode them. The consensus is that populations exhibit high levels of genetic polymorphism, most notably the genes encoding surface proteins of the merozoite (Msp1, Msp2) and the sporozoite (Csp). The age and derivation of this variation is a subject that warrants further careful consideration, as discussed here by Stephen Rich, Marcelo Ferreira and Francisco Ayala.

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恶性疟原虫抗原多样性的起源
大多数关于恶性疟原虫遗传变异的研究都集中在蛋白质抗原和编码它们的基因上。一致认为,群体表现出高水平的遗传多态性,最明显的是编码裂殖子(Msp1, Msp2)和孢子子(Csp)表面蛋白的基因。正如Stephen Rich、Marcelo Ferreira和Francisco Ayala所讨论的,这种变异的年龄和起源是一个值得进一步仔细考虑的问题。
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Websites of interest Neosporosis. Seeking new targets for antiparasitic agents Response from A. Serero et al. Parasitology nomenclature – a recommendation Implications for neonatal HIV/AIDS and TB of sensitization in utero to helminths
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