Assignment of seta to distal mouse X chromosome by radiation hybrid mapping.

Abstract

The Seta (SH3 containing, expressed in tumorigenic astrocytes) gene, originally isolated from rat, is expressed in association with malignant transformation in astrocytes and in human gliomas (Bögler et al., 2000). It is part of a new family of adapter molecules with three SH3 domains, which includes CD2AP (Dustin et al., 1998) and CMS (Kirsch et al., 1999). These molecules interact with cytoskeletal and cell signaling proteins. In order to identify Seta’s chromosome location we have mapped it in the mouse genome using radiation hybrids.