Molecular cloning, chromosomal localization, and expression of the murine SALL1 ortholog Sall1.

A Buck, L Archangelo, C Dixkens, J Kohlhase
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引用次数: 42

Abstract

SALL1 has been identified as one of now three human homologs of the region specific homeotic gene spalt (sal) of Drosophila, which encodes a zinc finger protein of characteristic structure. Mutations of SALL1 on chromosome 16q12.1 cause Townes-Brocks syndrome (TBS, OMIM no. 107480). In order to facilitate functional studies of this gene in a model organism, we searched for the murine homolog of SALL1. Here we report the genomic cloning, chromosome mapping, and partial expression analysis of the gene Sall1. Sequence comparison, Northern blot hybridization as well as the conserved chromosome location on the homologous mouse chromosome indicate that we have indeed isolated the murine homolog of SALL1.

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小鼠SALL1同源基因SALL1的克隆、染色体定位及表达。
SALL1已被确定为果蝇区域特异性同源基因spalt (sal)的三个人类同源物之一,该基因编码具有特征结构的锌指蛋白。染色体16q12.1上的SALL1突变导致汤斯-布罗克斯综合征(TBS, OMIM no. 12)。107480)。为了促进该基因在模式生物中的功能研究,我们寻找了SALL1的小鼠同源物。本文报道了基因Sall1的基因组克隆、染色体定位和部分表达分析。序列比较、Northern blot杂交以及同源小鼠染色体上保守的染色体定位表明,我们确实分离到了SALL1的小鼠同源物。
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