The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9.

Z Gu, D J Gilbert, V A Valentine, N A Jenkins, N G Copeland, G P Zambetti
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引用次数: 17

Abstract

Activation of the p53 tumor suppressor leads to either a cell cycle arrest or to apoptosis and the factors that influence these responses are poorly understood. It is clear, however, that p53 regulates these processes by inducing a series of downstream target genes. One recently identified p53-target gene, EI24 (alias PIG8), induces apoptosis when ectopically expressed. To better understand the biological properties of EI24 and its potential relevance to disease, in particular cancer, we determined the chromosomal location and pattern of gene expression of EI24. EI24 is widely expressed in adult tissues and throughout mouse embryogenesis. The genomic locus of EI24 was mapped to the proximal region of mouse chromosome 9 and human chromosome 11q23-->q24, a region frequently altered in human cancers. These results suggest that EI24 may play an important role in the p53 tumor suppressor pathway.

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p53诱导基因EI24/PIG8定位于人类染色体11q23和小鼠染色体9的近端区域。
p53肿瘤抑制因子的激活导致细胞周期阻滞或细胞凋亡,而影响这些反应的因素尚不清楚。然而,很明显,p53通过诱导一系列下游靶基因来调节这些过程。最近发现的p53靶基因EI24(别名PIG8)在异位表达时可诱导细胞凋亡。为了更好地了解EI24的生物学特性及其与疾病,特别是癌症的潜在相关性,我们确定了EI24的染色体位置和基因表达模式。EI24在成年组织和整个小鼠胚胎发生过程中广泛表达。e24的基因组位点定位于小鼠9号染色体和人类11q23- >q24染色体的近端区域,该区域在人类癌症中经常发生改变。这些结果提示EI24可能在p53肿瘤抑制通路中发挥重要作用。
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