Assignment of interleukin-1 receptor, type I (IL1R1) to bovine chromosome band 11q12 by in situ hybridization.

B Castiglioni, S Comincini, M G Foti, L Ferretti
{"title":"Assignment of interleukin-1 receptor, type I (IL1R1) to bovine chromosome band 11q12 by in situ hybridization.","authors":"B Castiglioni, S Comincini, M G Foti, L Ferretti","doi":"10.1159/000015605","DOIUrl":null,"url":null,"abstract":"Interleukin-1 (IL-1) is an inflammatory cytokine involved in inflammation and immune responses (Dinarello, 1988). The IL-1 family is complex, with three ligands (IL-1·, IL-1ß and the IL-1 receptor antagonist) and two receptors (type I, IL-1R1 and type II, IL-1R2). IL-1R1, present in low numbers on most cells, is the predominant receptor on T-cells and fibroblasts (Sims et al., 1988). IL-1R2 is mainly expressed in neutrophils, B cells and monocytes (McMahan et al., 1991). The human and murine IL-1 receptors are transcribed from separate genes and have been assigned to HSA2 and to MMU1, respectively (Copeland et al., 1991). The bovine IL-1 receptor subtypes have been mapped to BTA11 by linkage analysis (Yoo et al., 1994; Kappes et al., 1997). ZOO-FISH data (Solinas-Toldo et al., 1995) indicate that most of HSA 2q corresponds to BTA 2q12→q44. On the contrary, IL1B (HSA 2q14), is the first locus beyond a breakpoint proximal to PROC (HSA 2q13→ q14) that defines a region of synteny with BTA11 (Lopez-Corrales et al., 1998). Our data assign IL1R1 to BTA 11q12, at a greater distance from IL1B (BTA 11q21→q23) compared to man where the genes are placed in the same chromosomal subregion (HSA 2q12 and 2q14 respectively). Fig. 1. Chromosomal localisation of the bovine IL-1R1 gene. (a) Partial metaphase spread showing a typical FISH with the IL1R1 probe on BTA 11q12. (b) Ideogram of BTA11 showing the position of IL1R1.","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015605","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cytogenetics and cell genetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000015605","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Interleukin-1 (IL-1) is an inflammatory cytokine involved in inflammation and immune responses (Dinarello, 1988). The IL-1 family is complex, with three ligands (IL-1·, IL-1ß and the IL-1 receptor antagonist) and two receptors (type I, IL-1R1 and type II, IL-1R2). IL-1R1, present in low numbers on most cells, is the predominant receptor on T-cells and fibroblasts (Sims et al., 1988). IL-1R2 is mainly expressed in neutrophils, B cells and monocytes (McMahan et al., 1991). The human and murine IL-1 receptors are transcribed from separate genes and have been assigned to HSA2 and to MMU1, respectively (Copeland et al., 1991). The bovine IL-1 receptor subtypes have been mapped to BTA11 by linkage analysis (Yoo et al., 1994; Kappes et al., 1997). ZOO-FISH data (Solinas-Toldo et al., 1995) indicate that most of HSA 2q corresponds to BTA 2q12→q44. On the contrary, IL1B (HSA 2q14), is the first locus beyond a breakpoint proximal to PROC (HSA 2q13→ q14) that defines a region of synteny with BTA11 (Lopez-Corrales et al., 1998). Our data assign IL1R1 to BTA 11q12, at a greater distance from IL1B (BTA 11q21→q23) compared to man where the genes are placed in the same chromosomal subregion (HSA 2q12 and 2q14 respectively). Fig. 1. Chromosomal localisation of the bovine IL-1R1 gene. (a) Partial metaphase spread showing a typical FISH with the IL1R1 probe on BTA 11q12. (b) Ideogram of BTA11 showing the position of IL1R1.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
白细胞介素-1受体I型(IL1R1)在牛染色体带11q12上的原位杂交。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Spectral karyotyping of the human colon cancer cell lines SW480 and SW620. Analysis of genetic heterogeneity among five gynogenetic clones of silver crucian carp, Carassius auratus gibelio Bloch, based on detection of RAPD molecular markers. Cloning, characterization, and physical mapping of the canine Prop-1 gene (PROP1): exclusion as a candidate for combined pituitary hormone deficiency in German shepherd dogs. Spectral karyotyping of the human colon cancer cell lines SW480 and SW620. Murine chromosome 16 telomeric region, homologous with human chromosome 21q22, contains the osmoregulatory Na(+)/myo-inositol cotransporter (SLC5A3) gene.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1