The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas.

Y Liu, E McKenna, D J Figueroa, R Blevins, C P Austin, P B Bennett, R Swanson
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引用次数: 22

Abstract

A novel human Kir5.1 (inward rectifier K+ channel subunit, gene name KCNJ16) was identified through database searches. This human KCNJ16 was mapped to chromosome 17q25. The full-length cDNA was identified and its genomic structure was determined. Tissue distribution studies showed that human KCNJ16 is significantly expressed in human kidney, pancreas and thyroid gland. In situ hybridization revealed expression in convoluted tubule cells of kidney and in the acinar and ductal cells of pancreas. These suggest that human Kir5.1 may be involved in the regulation of fluid and pH balance, thus making it a potential therapeutic target for hypertension, renal failure, or pancreatic disease.

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人类内向的K(+)通道亚基kir5.1 (KCNJ16)定位于染色体17q25,在肾脏和胰腺中表达。
通过数据库检索,发现了一个新的人类Kir5.1(内向整流K+通道亚基,基因名KCNJ16)。该人类KCNJ16定位于染色体17q25。鉴定全长cDNA并确定其基因组结构。组织分布研究表明,KCNJ16在人体肾脏、胰腺和甲状腺中均有显著表达。原位杂交显示在肾脏的曲小管细胞和胰腺的腺泡和导管细胞中表达。这表明人类Kir5.1可能参与体液和pH平衡的调节,从而使其成为高血压、肾衰竭或胰腺疾病的潜在治疗靶点。
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