Anthony W O'Regan , Gerard J Nau , Geoffrey L Chupp , Jeffrey S Berman
{"title":"Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks","authors":"Anthony W O'Regan , Gerard J Nau , Geoffrey L Chupp , Jeffrey S Berman","doi":"10.1016/S0167-5699(00)01715-1","DOIUrl":null,"url":null,"abstract":"<div><p>Previously regarded as an adhesive bone matrix protein, recent studies suggest that osteopontin (Eta-1) is also a novel RGD-containing cytokine that regulates early cell-mediated immunity. Proteins related to the extracellular matrix may function as important modulators of immune responses.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Pages 475-478"},"PeriodicalIF":0.0000,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01715-1","citationCount":"175","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunology today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167569900017151","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 175
Abstract
Previously regarded as an adhesive bone matrix protein, recent studies suggest that osteopontin (Eta-1) is also a novel RGD-containing cytokine that regulates early cell-mediated immunity. Proteins related to the extracellular matrix may function as important modulators of immune responses.