Young-Yun Kong , William J Boyle , Josef M Penninger
{"title":"Osteoprotegerin ligand: a regulator of immune responses and bone physiology","authors":"Young-Yun Kong , William J Boyle , Josef M Penninger","doi":"10.1016/S0167-5699(00)01718-7","DOIUrl":null,"url":null,"abstract":"<div><p>The TNF-family molecule osteoprotegerin<span> ligand (OPGL, also known as TRANCE, RANKL and ODF) is a key regulator of bone remodeling and essential for the development and activation of osteoclasts<span>. Intriguingly, OPGL also regulates T cell–dendritic cell communications, dendritic cell survival and lymph-node organogenesis. Here, Young-Yun Kong and colleagues discuss the role of OPGL, and its receptor RANK, in the immune system and in bone metabolism.</span></span></p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Pages 495-502"},"PeriodicalIF":0.0000,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01718-7","citationCount":"170","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunology today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167569900017187","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 170
Abstract
The TNF-family molecule osteoprotegerin ligand (OPGL, also known as TRANCE, RANKL and ODF) is a key regulator of bone remodeling and essential for the development and activation of osteoclasts. Intriguingly, OPGL also regulates T cell–dendritic cell communications, dendritic cell survival and lymph-node organogenesis. Here, Young-Yun Kong and colleagues discuss the role of OPGL, and its receptor RANK, in the immune system and in bone metabolism.
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