Development of a new engineering-based capsule for human drug absorption studies

Ian Wilding , Peter Hirst , Alyson Connor
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引用次数: 121

Abstract

Over recent years, there has been a significant growth in the number of new drugs entering development with challenging pharmaceutical (e.g. solubility) and biopharmaceutical (e.g. permeability) properties. As a consequence, there is an increasing number of pharmaceutical companies using human absorption studies to provide a ‘route map’ for development. These projects are typically undertaken early in clinical development and utilize engineering-based capsules to provide non-invasive drug delivery to the selected sites of the human gut. The Enterion capsule has recently been developed to provide for the delivery of a wide range of different drug formulations, for example, solution, powder and granulate, into any region of the gut, both easily and efficiently.

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用于人体药物吸收研究的新型工程胶囊的研制
近年来,具有挑战性的药物(如溶解度)和生物制药(如渗透性)特性的新药数量显著增长。因此,越来越多的制药公司利用人体吸收研究为发展提供“路线图”。这些项目通常在临床开发的早期进行,利用基于工程的胶囊向人体肠道的选定部位提供非侵入性药物输送。Enterion胶囊最近被开发用于提供多种不同药物制剂的递送,例如,溶液,粉末和颗粒,进入肠道的任何区域,既容易又有效。
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