Sphingolipids: second messengers, mediators and raft constituents in signaling

Eva E Prieschl , Thomas Baumruker
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引用次数: 57

Abstract

Recently, evidence has accumulated to show that sphingolipids exert an important function in signaling. These lipids serve as intracellular second messengers and as extracellular mediators. Furthermore, glycosylated sphingolipids are essential components of membrane rafts, which serve as platforms for the initiation of signaling cascades. Here, Eva Prieschl and Thomas Baumruker summarize current findings in leukocytes illustrating these different facets.

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鞘脂:信号传导中的第二信使、介质和筏成分
近年来,越来越多的证据表明鞘脂在信号传导中起着重要的作用。这些脂质作为细胞内第二信使和细胞外介质。此外,糖基化鞘脂是膜筏的重要组成部分,作为信号级联反应启动的平台。在这里,Eva Prieschl和Thomas Baumruker总结了目前在白细胞中的发现,说明了这些不同的方面。
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