Dale I. Godfrey , Kirsten J.L. Hammond , Lynn D. Poulton , Mark J. Smyth , Alan G. Baxter
{"title":"NKT cells: facts, functions and fallacies","authors":"Dale I. Godfrey , Kirsten J.L. Hammond , Lynn D. Poulton , Mark J. Smyth , Alan G. Baxter","doi":"10.1016/S0167-5699(00)01735-7","DOIUrl":null,"url":null,"abstract":"<div><p>The proposed roles of NK1.1<sup>+</sup> T (NKT) cells in immune responses range from suppression of autoimmunity to tumor rejection. Heterogeneity of these cells contributes to the controversy surrounding their development and function. This review aims to provide an update on NKT cell biology and, whenever possible, to compare what is known about NKT-cell subsets.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Pages 573-583"},"PeriodicalIF":0.0000,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01735-7","citationCount":"959","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunology today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167569900017357","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 959
Abstract
The proposed roles of NK1.1+ T (NKT) cells in immune responses range from suppression of autoimmunity to tumor rejection. Heterogeneity of these cells contributes to the controversy surrounding their development and function. This review aims to provide an update on NKT cell biology and, whenever possible, to compare what is known about NKT-cell subsets.
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