How does TAP pump peptides? Insights from DNA repair and traffic ATPases

Eric A.J Reits, Alexander C Griekspoor, Jacques Neefjes
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引用次数: 31

Abstract

This article presents an integral model of TAP function that visualizes how peptide and ATP drive the conformational changes required for pore opening and peptide transfer into the major histocompatibility complex (MHC) class I loading complex.

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TAP是如何泵送肽的?从DNA修复和交通atp酶的见解
本文提出了一个完整的TAP功能模型,可视化肽和ATP如何驱动孔隙打开和肽转移到主要组织相容性复合体(MHC) I类负载复合体所需的构象变化。
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