K Ofuji, M Satake, Y Oshima, T McMahon, K J James, T Yasumoto
{"title":"A sensitive and specific determination method for azaspiracids by liquid chromatography mass spectrometry.","authors":"K Ofuji, M Satake, Y Oshima, T McMahon, K J James, T Yasumoto","doi":"10.1002/1522-7189(199911/12)7:6<247::aid-nt68>3.0.co;2-t","DOIUrl":null,"url":null,"abstract":"<p><p>A liquid chromatography/mass spectrometry (LC/MS) method was developed for the sensitive and specific determination of azaspiracid and its two analogs, the causative toxins of azaspiracid poisoning that occurred in the Netherlands and Ireland. The LC/MS method provided a detection limit of 50 pg for azaspiracid. The sensitivity was approximately 8 x 10(4) times greater than the mouse bioassay. The method was used to confirm the presence of azaspiracids in toxic mussels collected at Arranmore Island, Ireland in 1997.</p>","PeriodicalId":18777,"journal":{"name":"Natural toxins","volume":"7 6","pages":"247-50"},"PeriodicalIF":0.0000,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/1522-7189(199911/12)7:6<247::aid-nt68>3.0.co;2-t","citationCount":"52","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural toxins","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/1522-7189(199911/12)7:6<247::aid-nt68>3.0.co;2-t","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 52
Abstract
A liquid chromatography/mass spectrometry (LC/MS) method was developed for the sensitive and specific determination of azaspiracid and its two analogs, the causative toxins of azaspiracid poisoning that occurred in the Netherlands and Ireland. The LC/MS method provided a detection limit of 50 pg for azaspiracid. The sensitivity was approximately 8 x 10(4) times greater than the mouse bioassay. The method was used to confirm the presence of azaspiracids in toxic mussels collected at Arranmore Island, Ireland in 1997.
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