The possible involvement of 3-methoxy-2(5H)-furanone in the etiology of Narthecium asiaticum maxim. associated nephrotoxicity in cattle.

A Flåøyen, T L Torgersen, W Langseth
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Abstract

Two samples of Narthecium asiaticum Maxim leaves collected in Japan were found to contain 103 microg(-1) and 160 microg g(-1) dry matter of 3-methoxy-2(5H)-furanone respectively. 3-Methoxy-2(5h)-furanone was suggested to be the toxic principle of N. asiaticum causing nephrotoxicity in cattle in Japan. Two other furanones, which are thought to be non-toxic, were also isolated from the two samples. These were 4-methoxy-2(5H)-furanone and 5-hydroxy-4-methoxy-2(5H)-furanone.

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3-甲氧基-2(5H)-呋喃酮可能参与亚洲麻黄病的发病机制。牛的相关肾毒性。
在日本采集的两份亚洲麻叶样品中,3-甲氧基-2(5H)-呋喃酮的干物质含量分别为103 μ g(-1)和160 μ g(-1)。3-甲氧基-2(5h)-呋喃酮可能是引起日本牛肾毒性的亚洲散斑霉的致毒机理。另外两种被认为是无毒的呋喃酮也从这两个样本中分离出来。分别是4-甲氧基-2(5H)-呋喃酮和5-羟基-4-甲氧基-2(5H)-呋喃酮。
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Erratum: Alfonso D, Johnson HA, Colman-Saizarbitoria T, Presley CP, McCabe GP, McLaughlin JL (1996): SARs of annonaceous acetogenins in rat liver mitochondria. Nat Toxins 4:181-188. Advances in detection methods for fungal and algal toxins. HPLC/MS analysis of fusarium mycotoxins, fumonisins and deoxynivalenol. Neuronal binding of tetanus toxin compared to its ganglioside binding fragment (H(c)). A new type sandwich immunoassay for microcystin: production of monoclonal antibodies specific to the immune complex formed by microcystin and an anti-microcystin monoclonal antibody.
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