{"title":"Water as polar modifier in normal phase chiral separation of 2-oxo-3-piperidineacetamide analogue.","authors":"J G Ning","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A small amount of water present in a normal phase chiral HPLC with a Chiralcel OD column was found to be critical and necessary to separate a pharmaceutical chiral intermediate, 3-piperidineacetamide analogue. The amount of water in the normal mobile phase was optimized, and a likely mechanism of the separation was proposed.</p>","PeriodicalId":11752,"journal":{"name":"Enantiomer","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Enantiomer","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A small amount of water present in a normal phase chiral HPLC with a Chiralcel OD column was found to be critical and necessary to separate a pharmaceutical chiral intermediate, 3-piperidineacetamide analogue. The amount of water in the normal mobile phase was optimized, and a likely mechanism of the separation was proposed.
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