Chromosomal imbalances are associated with metastasis-free survival in breast cancer patients.

Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology Pub Date : 2002-01-01 DOI:10.1155/2002/820269

Michaela Aubele, Gert Auer, Herbert Braselmann, Jörg Nährig, Horst Zitzelsberger, Leticia Quintanilla-Martinez, Jan Smida, Axel Walch, Heinz Höfler, Martin Werner

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引用次数: 41

Abstract

Multiple chromosomal imbalances have been identified in breast cancer using comparative genomic hybridization (CGH). Their association with the primary tumors' potential for building distant metastases is unknown. In this study we have investigated 39 invasive breast carcinomas with a mean follow-up period of 99 months (max. 193 months) by CGH to determine the prognostic value of chromosomal gains and losses. The mean number of chromosomal imbalances per tumor was 6.5+/-0.7 (range 2 to 18). The most frequent alterations identified in more than 1/3 of cases were gains on chromosomes 11q13, 12q24, 16, 17, and 20q, and losses on 2q and 13q. A significantly different frequency of chromosomal aberrations (p

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染色体失衡与乳腺癌患者无转移生存相关。

使用比较基因组杂交(CGH)已确定乳腺癌中存在多染色体失衡。它们与原发肿瘤形成远处转移的可能性之间的关系尚不清楚。在这项研究中，我们调查了39例浸润性乳腺癌，平均随访时间为99个月(最长为99个月)。193个月)通过CGH来确定染色体获得和损失的预后价值。每个肿瘤的平均染色体不平衡数为6.5+/-0.7(范围2至18)。在超过1/3的病例中，最常见的改变是染色体11q13、12q24、16、17和20q上的增加，以及2q和13q上的损失。染色体畸变的频率显著不同(p

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Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology

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