Joel Nelson, Anna Bagnato, Bruno Battistini, Perry Nisen
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引用次数: 541
Abstract
Collectively, the endothelins and their receptors — referred to as the endothelin (ET) axis — have key physiological functions in normal tissue, acting as modulators of vasomotor tone, tissue differentiation, development, cell proliferation and hormone production. Based on new data, the ET axis also functions in the growth and progression of various tumours. Preliminary results from clinical trials, such as those with atrasentan — an ETA-receptor antagonist — in prostate cancer, are encouraging. The place of ET-receptor antagonists in cancer therapy for a range of malignancies merits further investigation.
内皮素及其受体统称为内皮素（ET）轴，在正常组织中具有关键的生理功能，是血管运动张力、组织分化、发育、细胞增殖和激素分泌的调节剂。根据新的数据，ET 轴还在各种肿瘤的生长和恶化过程中发挥作用。临床试验的初步结果令人鼓舞，例如用阿曲生坦（一种 ETA 受体拮抗剂）治疗前列腺癌。ET受体拮抗剂在各种恶性肿瘤的癌症治疗中的地位值得进一步研究。
期刊介绍：
Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.
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